Beilstein J. Nanotechnol.2019,10, 1666–1678, doi:10.3762/bjnano.10.162
Berlin, Germany Institute of Functional Interfaces, Karlsruher Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany 10.3762/bjnano.10.162 Abstract smartPearls are a dermaldeliverysystem for poorly soluble active agents, consisting of nanoporous silica
solvent removal) can be industrially realized in a commercial 50 L rotary evaporator.
Keywords: amorphous dispersion; bioavailability enhancement; dermaldeliverysystem; rutin; smartPearls; solubility enhancement; Introduction
Many interesting active agents in pharma and cosmetics are poorly soluble
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Figure 1:
From left to right: rutin/ethanol solution, silica dispersed in rutin solution attached to the rota...